Genomic Analysis of Salmonella enterica Serovar Typhimurium Definitive Phage Type 104

identified mainly carbapenem-hydrolyzing carbapenemase OXA-58 (9). Recently, we showed that the blaNDM-1 gene was carried by a composite transposon bracketed by 2 copies of ISAba125 in A. baumannii (10). Cloning and sequencing of the genetic context of the blaNDM-1 in the first isolate showed that transposon Tn125 was truncated at its 3′-end extremity by insertion sequence ISAba14, giving rise to a truncated Tn125 (ΔTn125). PCR mapping of all isolates showed that they possessed this truncated isoform of Tn125, which was therefore probably no longer functional. The identification of several clinical A. baumannii isolates that possessed the blaNDM-1 gene and originated from North Africa, with no obvious link to the Indian subcontinent, strongly suggests that 1 NDM-producing A. baumannii clone is probably widespread in North Africa and that it might now act as a reservoir for NDM-1. This finding might indicate that control of spread of multidrug-resistant A. baumannii would have a primary role in controlling spread of NDM-1.